An Iron(II) Chloride-Promoted Radical Cascade Methylation or α-Chloro-β-methylation of N-Arylacrylamides with Dimethyl Sulfoxide

被引：52

作者：

Li, Zejiang ^{[1
]}

Cui, Xiaosong ^{[1
]}

Niu, Lin ^{[1
]}

Ren, Yingming ^{[1
]}

Bian, Menghua ^{[1
]}

Yang, Xuebiao ^{[1
]}

Yang, Biao ^{[1
]}

Yan, Qinqin ^{[1
]}

Zhao, Jincan ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Hebei, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 02期

关键词：

N-arylacrylamides; alpha-chloro-beta-methylation; cyclization; methylation; radical reactions; C-H BONDS; PALLADIUM-CATALYZED ALKYLATION; ACTIVATED ALKENES; SIMPLE ALKANES; OXINDOLES; FUNCTIONALIZATION; ACCESS; ROUTE; ARENE;

D O I：

10.1002/adsc.201601001

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A free radical-initiated methylation and/or alpha-chloro-beta-methylation of N-arylacrylamides with dimethyl sulfoxide under the analogous Fenton reaction condition has been developed, which provides an effective and facile cascade strategy for the synthesis of oxindoles and chlorinated amides.

引用

页码：246 / 249

页数：4

共 3 条

[1] A Free-Radical Cascade Methylation/CyClization of N-Arylacrylamides and lsocyanides with Dicumyl Peroxide
Xu, Zhengbao
Yan, Chaoxian
Liu, Zhong-Quan
ORGANIC LETTERS, 2014, 16 (21) : 5670 - 5673
[2] Visible-Light-Promoted (Phenylsulfonyl)methylation of Electron-Rich Heteroarenes and N-Arylacrylamides
Liu, Fei
Li, Pixu
JOURNAL OF ORGANIC CHEMISTRY, 2016, 81 (16): : 6972 - 6979
[3] Visible-light-induced and iron-catalyzed methylation of N-arylacrylamides with dimethyl sulphoxide: a convenient access to 3-ethyl-3-methyl oxindoles
Xie, Zuguang
Li, Pinhua
Hu, Yu
Xu, Ning
Wang, Lei
ORGANIC & BIOMOLECULAR CHEMISTRY, 2017, 15 (19) : 4205 - 4211

← 1 →