Quantification of tenofovir disoproxil fumarate and emtricitabine in generic pre-exposure prophylaxis tablets obtained from the internet

被引：2

作者：

Wang, Xinzhu ^{[1
]}

Nutland, Will ^{[2
]}

Brady, Michael ^{[3
]}

Green, Ian ^{[3
]}

Boffito, Marta ^{[1
,4
]}

McClure, Myra ^{[1
]}

机构：

[1] Imperial Coll London, Dept Med, London, England

[2] PrEPster, London, England

[3] Terrence Higgins Trust, London, England

[4] Chelsea & Westminster Hosp, HIV GUM Dept, London, England

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2019年 / 30卷 / 08期

关键词：

Generic PrEP; HIV prevention; liquid chromatography; quantification; tablet form; MEN;

D O I：

10.1177/0956462419841144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, we addressed the recent concerns over the authenticity of generic pre-exposure prophylaxis (PrEP) purchased online by sampling 14 generic PrEPs from different manufacturers and suppliers and measuring tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) content using high-performance liquid chromatography. We confirmed that all the PrEP tablets contained 94.3% to 104.9% of the 300 mg of TDF claimed on the label and 97.3% to 104.4% of the 200 mg FTC claimed on the label.

引用

页码：765 / 768

页数：4

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