The use of the Gibbs sampler with fully conditionally specified models, where the distribution of each variable given the other variables is the starting point, has become a popular method to create imputations in incomplete multivariate data. The theoretical weakness of this approach is that the specified conditional densities can be incompatible, and therefore the stationary distribution to which the Gibbs sampler attempts to converge may not exist. This study investigates practical consequences of this problem by means of simulation. Missing data are created under four different missing data mechanisms. Attention is given to the statistical behavior under compatible and incompatible models. The results indicate that multiple imputation produces essentially unbiased estimates with appropriate coverage in the simple cases investigated, even for the incompatible models. Of particular interest is that these results were produced using only five Gibbs iterations starting from a simple draw from observed marginal distributions. It thus appears that, despite the theoretical weaknesses, the actual performance of conditional model specification for multivariate imputation can be quite good, and therefore deserves further study.
机构:
Royal Childrens Hosp, Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Melbourne, Vic, Australia
Univ Melbourne, Dept Paediat, Fac Med Dent & Hlth Sci, Melbourne, Vic, AustraliaRoyal Childrens Hosp, Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Melbourne, Vic, Australia
Lee, Katherine J.
Carlin, John B.
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Royal Childrens Hosp, Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Melbourne, Vic, Australia
Univ Melbourne, Dept Paediat, Fac Med Dent & Hlth Sci, Melbourne, Vic, AustraliaRoyal Childrens Hosp, Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Melbourne, Vic, Australia
机构:
Univ Calif Los Angeles, Dept Psychol, Box 951963, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Box 951963, Los Angeles, CA 90095 USA
Enders, Craig K.
Keller, Brian T.
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Univ Calif Los Angeles, Dept Psychol, Box 951963, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, Box 951963, Los Angeles, CA 90095 USA
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Univ London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, England
Bartlett, Jonathan W.
Seaman, Shaun R.
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MRC Biostat Unit, Cambridge, EnglandUniv London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, England
Seaman, Shaun R.
White, Ian R.
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MRC Biostat Unit, Cambridge, EnglandUniv London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, England
White, Ian R.
Carpenter, James R.
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Univ London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, England
MRC Clin Trials Unit, London, EnglandUniv London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, England
机构:
Univ Calif Los Angeles, Dept Psychol, 1285 Franz Hall,Box 951563, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, 1285 Franz Hall,Box 951563, Los Angeles, CA 90095 USA
Keller, Brian T.
Du, Han
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Univ Calif Los Angeles, Dept Psychol, 1285 Franz Hall,Box 951563, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Psychol, 1285 Franz Hall,Box 951563, Los Angeles, CA 90095 USA
机构:
Univ London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, England
Bartlett, Jonathan W.
Morris, Tim P.
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UCL, MRC Clin Trials Unit, Inst Clin Trials & Methodol, London, England
Univ London London Sch Hyg & Trop Med, London WC1E 7HT, EnglandUniv London London Sch Hyg & Trop Med, Dept Med Stat, London WC1E 7HT, England
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Univ London, London Sch Hyg & Trop Med, London WC1E 7HU, EnglandUniv Tampere, Tampere Sch Publ Hlth, Tampere 33014, Finland
Kenward, Michael G.
Virtanen, Suvi A.
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Univ Tampere, Tampere Sch Publ Hlth, Tampere 33014, Finland
Natl Inst Hlth & Welf, Helsinki, FinlandUniv Tampere, Tampere Sch Publ Hlth, Tampere 33014, Finland
机构:
Univ Calif Los Angeles, Los Angeles, CA USA
Univ Calif Los Angeles, Dept Psychol, 3586 Franz Hall,502 Portola Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Los Angeles, CA USA
Enders, Craig K.
Hayes, Timothy
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Florida Int Univ, Miami, FL 33199 USAUniv Calif Los Angeles, Los Angeles, CA USA
Hayes, Timothy
Du, Han
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Univ Calif Los Angeles, Dept Psychol, 3586 Franz Hall,502 Portola Plaza, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Los Angeles, CA USA