Russujaponols A-F, illudoid sesquiterpenes from the fruiting body of Russula japonica

Six new illudoid sesquiterpenes, russujaponols A-F (1-6), were isolated from the fruiting bodies of Russula japonica Hongo. Their structures were established primarily by 2D NMR experiments, and the structure of the main compound, russujaponol A ( 1), was confirmed by X-ray crystallographic analysis of its benzoate (1a). Russujaponol A ( 1) suppressed invasion of human fibrosarcoma (HT1080) cells into Matrigel in a concentration-dependent manner and caused 63% inhibition at 3.73 mu M.