Evaluation of CEDIA and DRI Drugs of Abuse Immunoassays for Urine Screening on a Thermo Indiko Plus Analyzer

被引：12

作者：

Koehler, Katharina M. ^{[1
]}

Hammer, Raija ^{[1
]}

Riedy, Kathrin ^{[1
]}

Auwaerter, Volker ^{[1
]}

Neukamm, Merja A. ^{[1
]}

机构：

[1] Univ Freiburg, Inst Forens Med, Med Ctr, Fac Med, Freiburg, Germany

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2017年 / 31卷 / 01期

关键词：

abstinence control; diagnostic tests; ethyl glucuronide; forensic toxicology; VALIDATION; KITS;

D O I：

10.1002/jcla.22021

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: For analysis of urine samples during abstinence control for driving ability assessment (medical and psychological assessment, MPA), a reliable screening method for ethyl glucuronide and drugs of abuse (cannabinoids, opiates, cocaine, amphetamines, methadone, and benzodiazepines) is needed. Methods: In this study CEDIA and DRI immunoassays were applied on a Thermo Fisher Scientific Indiko Plus analyzer. Precision and accuracy as well as sensitivity and specificity at the required cut-offs for the MPA were evaluated. Results: The specificity was satisfactory and ranged from 91% for methamphetamine to 100% for opiates, cocaine metabolite, amphetamine, EDDP, and benzodiazepines. Moreover, sensitivity was 100% for all assays except for cannabinoids (91%). Conclusion: The presented method can therefore be recommended for abstinence control. (C) 2016 Wiley Periodicals, Inc.

引用

页数：6

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