Quinoline-Fused Lactones via Tandem Oxidation Cyclization: Metal-Free sp3 C-H Functionalization

被引：8
|
作者：
Garia, Alankrita [1 ]
Chauhan, Parul [1 ]
Halder, Riya [1 ]
Jain, Nidhi [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, New Delhi 110016, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 01期
关键词：
ONE-POT SYNTHESIS; ACID DERIVATIVES; LACTONIZATION; ARYLATION; ACTIVATION; AMIDATION; EFFICIENT;
D O I：
10.1021/acs.joc.0c02238
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A unique lactonization of 2-methyl-3-acyl-4-phenylquinolines using PhIO as the oxidant and selectfluor as an additive is reported. The reaction occurs under ambient conditions through tandem oxidation and cyclization of sp(3) C-H bonds under metal-free conditions. The heterocycle-fused lactones are obtained in moderate to good yield.
引用
收藏
页码：538 / 546
页数：9
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