Differences in Antibody Responses Between Trivalent Inactivated Influenza Vaccine and Live Attenuated Influenza Vaccine Correlate With the Kinetics and Magnitude of Interferon Signaling in Children

被引:63
|
作者
Cao, Raquel G. [1 ]
Suarez, Nicolas M. [1 ]
Obermoser, Gerlinde [4 ]
Lopez, Santiago M. C. [1 ]
Flano, Emilio [1 ]
Mertz, Sara E. [1 ]
Albrecht, Randy A. [5 ,6 ]
Garcia-Sastre, Adolfo [5 ,6 ,7 ]
Mejias, Asuncion [1 ,2 ,3 ]
Xu, Hui [4 ]
Qin, Huanying [4 ]
Blankenship, Derek [4 ]
Palucka, Karolina [4 ]
Pascual, Virginia [4 ]
Ramilo, Octavio [1 ,2 ,3 ]
机构
[1] Res Inst, Ctr Vaccines & Immun, Columbus, OH USA
[2] Nationwide Childrens Hosp, Div Infect Dis, Dept Pediat, Columbus, OH USA
[3] Ohio State Univ, Coll Med, Columbus, OH 43205 USA
[4] Baylor Res Inst, Baylor Inst Immunol Res, Dallas, TX USA
[5] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA
[6] Icahn Sch Med Mt Sinai, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA
[7] Icahn Sch Med Mt Sinai, Dept Med, Div Infect Dis, New York, NY 10029 USA
来源
JOURNAL OF INFECTIOUS DISEASES | 2014年 / 210卷 / 02期
基金
美国国家卫生研究院;
关键词
Influenza vaccine; LAIV; TIV; children; interferon; HI antibodies; neutralizing antibodies; ALUMINUM-HYDROXIDE; IMMUNE-RESPONSE; A/H5N1; VACCINE; YOUNG-CHILDREN; EFFICACY; SAFETY; VIRUS; BURDEN; IMMUNOGENICITY; IMMUNIZATION;
D O I
10.1093/infdis/jiu079
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Live attenuated influenza vaccine (LAIV) and trivalent inactivated influenza vaccine (TIV) are effective for prevention of influenza virus infection in children, but the mechanisms associated with protection are not well defined. Methods. We analyzed the differences in B-cell responses and transcriptional profiles in children aged 6 months to 14 years immunized with these 2 vaccines. Results. LAIV elicited a significant increase in naive, memory, and transitional B cells on day 30 after vaccination, whereas TIV elicited an increased number of plasmablasts on day 7. Antibody titers against the 3 vaccine strains (H1N1, H3N2, and B) were significantly higher in the TIV group and correlated with number of antibody-secreting cells. Both vaccines induced overexpression of interferon (IFN)-signaling genes but with different kinetics. TIV induced expression of IFN genes on day 1 after vaccination in all age groups, and LAIV induced expression of IFN genes on day 7 after vaccination but only in children <5 years old. IFN-related genes overexpressed in both vaccinated groups correlated with H3N2 antibody titers. Conclusions. These results suggest that LAIV and TIV induced significantly different B-cell responses in vaccinated children. Early induction of IFN appears to be important for development of antibody responses.
引用
收藏
页码:224 / 233
页数:10
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