Catalytic Asymmetric Synthesis of 2,2-Disubstituted Oxetanes from Ketones by Using a One-Pot Sequential Addition of Sulfur Ylide

被引：61
|
作者：
Sone, Toshihiko [1 ]
Lu, Gang [1 ]
Matsunaga, Shigeki [1 ]
Shibasaki, Masakatsu [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 09期
关键词：
asymmetric synthesis; homogeneous catalysis; oxetanes; rare-earth metals; ylides; DIMETHYLOXOSULFONIUM METHYLIDE; KINETIC RESOLUTION; SUBSTITUTED OXETANES; EPOXIDE HYDROLASES; ACHIRAL ADDITIVES; COMPLEX; ENONES; POLYMERIZATION; OXIDATION; OLEFINS;
D O I：
10.1002/anie.200805473
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Better the second time around: The title compounds were synthesized by using a one-pot double methylene transfer catalyzed by a heterobimetallic La/Li complex. Chiral amplification in the second step was the key to obtaining oxetanes in high enantiomeric excess (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1677 / 1680
页数：4
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