Two single nucleotide polymorphisms (SNPs) in the CALL gene for association studies with IQ

被引：10
|
作者：
Angeloni, D [1 ]
Wei, MH [1 ]
Lerman, MI [1 ]
机构：
[1] NCI, Immunobiol Lab, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
来源：
PSYCHIATRIC GENETICS | 1999年 / 9卷 / 03期
关键词：
CALL; CEPH; IQ; SNPs; SSCP; 3p-sundrome;
D O I：
10.1097/00041444-199909000-00011
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A number of genes underlie the molecular bases of intelligence. Among these is probably CALL, a novel member of the L1 gene family of neural cell adhesion molecules. By using the single strand conformation polymorphism (SSCP) protocol, we screened the regions of the CALL gene corresponding to the 5' and 3' untranslated regions (UTRs) of the CALL mRNA, searching for polymorphisms that could be useful in association studies in the field of intelligence. We report the finding of T-to-A and T-to-C single nucleotide polymorphisms (SNPs) in the 3' UTR of CALL. These SNPs have an index of heterozygosity of 0.13 and 0.10, respectively, Research is in progress to understand the association between these variants and high IQ. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码：165 / 167
页数：3
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