Long non-coding RNA CCAT1 promotes the migration and invasion of prostate cancer PC-3 cells

被引：0

作者：

Chen, H. ^{[1
]}

He, Y. ^{[1
]}

Hou, Y. -S. ^{[1
]}

Chen, D. -Q. ^{[2
]}

He, S. -L. ^{[1
]}

Cao, Y. -F. ^{[1
]}

Wu, X. -M. ^{[1
]}

机构：

[1] First Hosp Jiaxing, Dept Urol Surg, Jiaxing, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Med Oncol, Suzhou, Peoples R China

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2018年 / 22卷 / 10期

关键词：

CCAT1; Prostate cancer; Proliferation; Migration; Invasion; POOR-PROGNOSIS; GASTRIC-CANCER; C-MYC; PROGRESSION; METASTASIS; EXPRESSION; APOPTOSIS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: To investigate the effect of long non-coding RNA CCAT1 on the proliferation, migration, and invasion of prostate cancer PC-3 cells. PATIENTS AND METHODS: The expression of CCAT1 was detected by Real-time PCR. The effect of CCAT1 down-regulation on the proliferation of PC-3 cells was observed by MTT assay. The regulatory of CCAT1 low-expression on the migration ability of PC-3 cells was investigated by transwell assay. The influence of decreased CCAT1 on the invasion ability of PC-3 cells was detected by Matrigel invasion assay. RESULTS: Increased CCAT1 was significantly related to lymph node metastasis in prostate cancer. Low-expression of CCAT1 could suppress cell proliferation. Knockdown of CCAT1 inhibited the migration of PC-3 cells. Down-regulation of CCAT1 attenuated the invasion of PC-3 cells. CONCLUSIONS: CCAT1 promoted the growth and the metastasis of prostate cancer. Our findings might provide a potential target for the diagnosis and treatment of prostate cancer.

引用

页码：2991 / 2996

页数：6

共 50 条

[1] Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer
Cao, Yuan
Shi, Huirong
Ren, Fang
Jia, Yanyan
Zhang, Ruitao
EXPERIMENTAL CELL RESEARCH, 2017, 359 (01) : 185 - 194
[2] Long non-coding RNA CCAT1 that can be activated by c-Myc promotes pancreatic cancer cell proliferation and migration
Yu, Qiuyun
Zhou, Xinfeng
Xia, Qing
Shen, Jia
Yan, Jia
Zhu, Jiuting
Li, Xiang
Shu, Ming
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2016, 8 (12): : 5444 - 5454
[3] Identification of long non-coding RNA CCAT1 as an oncogene in nasopharyngeal carcinoma
Dong, Yameng
Yuan, Haozhan
Jin, Guangyu
ONCOLOGY LETTERS, 2018, 16 (02) : 2750 - 2756
[4] CCAT1: a pivotal oncogenic long non-coding RNA in human cancers
Xin, Yu
Li, Zheng
Shen, Jianxiong
Chan, Matthew T. V.
Wu, William Ka Kei
CELL PROLIFERATION, 2016, 49 (03) : 255 - 260
[5] Long non-coding RNA CCAT1/miR-148a/PKCζ prevents cell migration of prostate cancer by altering macrophage polarization
Liu, Jie
Ding, Degang
Jiang, Zhaoqiang
Du, Tao
Liu, Jianjun
Kong, Zhaohui
PROSTATE, 2019, 79 (01): : 105 - 112
[6] The long, non-coding RNA CCAT1 is overexpressed in Endometrial Cancer and regulates Growth and Transcriptome of Endometrial Cancer Cells
Schueler-Toprak, S.
Skrzypczak, M.
Weber, F.
Ortmann, O.
Treeck, O.
GEBURTSHILFE UND FRAUENHEILKUNDE, 2020, 80 (07) : 740 - 741
[7] Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells
Schueler-Toprak, S.
Skrzypczak, M.
Weber, F.
Ortmann, O.
Treeck, O.
GEBURTSHILFE UND FRAUENHEILKUNDE, 2020, 80 (10) : E206 - E206
[8] Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells
Treeck, Oliver
Skrzypczak, Maciej
Schueler-Toprak, Susanne
Weber, Florian
Ortmann, Olaf
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2020, 122
[9] Long Non-coding RNA CCAT1 Acts as an Oncogene and Promotes Sunitinib Resistance in Renal Cell Carcinoma
Shan, Liping
Liu, Wei
Zhan, Yunhong
FRONTIERS IN ONCOLOGY, 2020, 10
[10] Exploring the role of CCAT1 and CCAT2 long non-coding RNA in colorectal carcinoma metastasis
Thean, L.
Li, H.
Lo, M.
Wong, M.
Tang, C.
Tan, K.
Cheah, P.
EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 1558 - 1558

← 1 2 3 4 5 →