Enzymatic kinetic resolution of sec-alcohols using an ionic liquid anhydride as acylating agent

被引：14

作者：

Teixeira, Raquel ^{[1
]}

Lourenco, Nuno M. T. ^{[1
]}

机构：

[1] Ctr Biol & Chem Engn, IBB, Inst Super Tecn, P-1049001 Lisbon, Portugal

来源：

TETRAHEDRON-ASYMMETRY | 2014年 / 25卷 / 12期

关键词：

CANDIDA-ANTARCTICA LIPASE; SUCCINIC ANHYDRIDE; ALKYL ALCOHOLS; BIOCATALYSIS; BIOTRANSFORMATIONS; SUBSTRATE;

D O I：

10.1016/j.tetasy.2014.05.001

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A task-specific ionic liquid bearing an anhydride moiety was synthesized for the first time in good yield (83%) through a carbodiimide-mediated coupling reaction. The enantiomeric separation of a series of sec-alcohols was performed via enzymatic kinetic resolution, employing an ionic anhydride as acylating agent and Candida antarctica Lipase B as a biocatalyst. A fast and efficient recovery of both enantiomers was achieved separately due to the ionic nature of the acyl donor, combined with the possibility of carrying out the enzymatic step in an organic solvent. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：944 / 948

页数：5

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