Droplet-based label-free detection system based on guided-mode resonance and electrowetting-on-dielectric for concentration measurement

被引:4
|
作者
Wang, Ying-Bin [1 ]
Su, Lin-Yun [1 ]
Fu, Ching-Shu [1 ]
Huang, Cheng-Sheng [1 ]
Hsu, Wensyang [1 ]
机构
[1] Natl Chiao Tung Univ, Dept Mech Engn, Hsinchu 30010, Taiwan
关键词
DIGITAL MICROFLUIDICS; BIOSENSORS; OPTIMIZATION; IMMUNOASSAY; FABRICATION; PROTEINS; SENSORS; DESIGN; FILTER; SERUM;
D O I
10.7567/JJAP.56.050313
中图分类号
O59 [应用物理学];
学科分类号
摘要
We demonstrate a digital microfluidic system with an on-chip detection capability that is based on a guided-mode resonance filter (GMRF). Versatile droplet manipulation was achieved through the electrowetting-on-dielectric (EWOD) technique. GMRF was fabricated through replica molding and soft lithography, and the EWOD chip was fabricated through a typical photolithography process. Droplets measuring 1.125 mu L were used to demonstrate merging, mixing, and cutting, and to achieve twofold and Threefold dilutions, and were then transported to the GMRF region for concentration measurement. The bulk sensitivity of GMRF is approximately 90 nm RIU-1 1 [17494nm/(g/L)], resulting in a minimum detectable concentration of 4.66 x 10(-5) g/L for a sucrose solution. (C) 2017 The Japan Society of Applied Physics
引用
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页数:4
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