Increase of caspase-3 activity by lignans from Machilus thunbergii in HL-60 cells

被引：41
|
作者：
Park, BY
Min, BS
Kwon, OK
Oh, SR
Ahn, KS
Kim, TJ
Kim, DY
Bae, KW
Lee, HK [1 ]
机构：
[1] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea
[2] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 08期
关键词：
Machilus thunbergii; lignan; caspase-3; DNA fragmentation; apoptosis;
D O I：
10.1248/bpb.27.1305
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nine lignans and two butanolides were isolated from the stem bark of Machilus thunbergii and their structures were identified as machilin A (1), licarin B (2), zuonin B (3), macelignan (4), secoisolancifolide (5), isolancifolide (6), oleiferin C (7), meso-dihydroguaiaretic acid (8), licarin A (9), machilin F (10), and nectandrin B (11) by spectroscopic means. These compounds were assessed for their abilities to activate a caspase-3 activity in human promyeloid leukemic HL-60 cells. The intracellular caspase-3 activity of macelignan (4), oleiferin C (7), meso-dihydroguaiaretic acid (8), and licarin A (9) increased approximately 3.04, 6.16, 2.10, and 3.10-fold at 100 mum over that of untreated control. In addition, compounds 4, 7, 8, and 9 induced internucleosomal DNA fragmentation in HL-60 cells.
引用
收藏
页码：1305 / 1307
页数：3
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