New therapeutic perspectives on protein-bound uremic toxins in chronic kidney disease

被引：5
|
作者：
Malyszko, Jolanta [1 ,2 ]
机构：
[1] Med Univ, Dept Nephrol 2, PL-15276 Bialystok, Poland
[2] Hypertens Dialysis Unit, PL-15276 Bialystok, Poland
来源：
EXPERT OPINION ON THERAPEUTIC TARGETS | 2014年 / 18卷 / 02期
关键词：
AST-120; chronic kidney disease; indoxyl sulfate; uremic toxins; CHRONIC-RENAL-FAILURE; P-CRESOL SULFATE; INDOXYL SULFATE; DIALYZER MEMBRANE; ORAL ADSORBENT; REMOVAL; AST-120; HEMODIALYSIS; PROGRESSION; SOLUTES;
D O I：
10.1517/14728222.2014.860966
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The uremic syndrome is a complex mosaic of clinical alterations that may be attributable to one or more of these different solutes. Uremic symptoms in patients with chronic kidney disease are primarily a consequence of inadequate removal and subsequent accumulation of organic products normally metabolized or excreted by the kidney.
引用
收藏
页码：109 / 113
页数：5
相关论文
共 50 条
  • [1] Targeting protein-bound uremic toxins in chronic kidney disease
    Niwa, Toshimitsu
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2013, 17 (11) : 1287 - 1301
  • [2] Protein-Bound Uremic Toxins: New Culprits of Cardiovascular Events in Chronic Kidney Disease Patients
    Ito, Shunsuke
    Yoshida, Masayuki
    TOXINS, 2014, 6 (02) : 665 - 678
  • [3] THE ROLE OF PROTEIN-BOUND UREMIC TOXINS ON EPO LEVELS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
    Lin Cheng-Jui
    Ma Ming-Chun
    Pan Chi-Feng
    Chen Han-Hsiang
    Wu Chih-Jen
    NEPHROLOGY, 2014, 19 : 124 - 124
  • [4] Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders
    Zhang, Shihan
    Tang, Shasha
    Liu, Yalei
    Xue, Binghua
    Xie, Qinyuan
    Zhao, Lingyun
    Yuan, Huijuan
    FRONTIERS IN ENDOCRINOLOGY, 2025, 16
  • [5] Protein-Bound Uremic Toxins ... New Targets to Prevent Insulin Resistance and Dysmetabolism in Patients With Chronic Kidney Disease
    Soulage, Christophe O.
    Koppe, Laetitia
    Fouque, Denis
    JOURNAL OF RENAL NUTRITION, 2013, 23 (06) : 464 - 466
  • [6] Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis
    Yang, Yi
    Mihajlovic, Milos
    Masereeuw, Rosalinde
    BIOMEDICINES, 2023, 11 (09)
  • [7] Predictive value of protein-bound uremic toxins for heart failure in patients with chronic kidney disease
    Zwaenepoel, Bert
    De Backer, Tine
    Glorieux, Griet
    Verbeke, Francis
    ESC HEART FAILURE, 2024, 11 (01): : 466 - 474
  • [8] Protein-Bound Uremic Toxins from Gut Microbiota and Inflammatory Markers in Chronic Kidney Disease
    Borges, Natalia A.
    Barros, Amanda F.
    Nakao, Lia S.
    Dolenga, Carla J.
    Fouque, Denis
    Mafra, Denise
    JOURNAL OF RENAL NUTRITION, 2016, 26 (06) : 396 - 400
  • [9] PREDICTIVE VALUE OF PROTEIN-BOUND UREMIC TOXINS FOR HEART FAILURE EVENTS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
    Zwaenepoel, Bert
    de Backer, Tine
    van Biesen, Wim
    Glorieux, Griet
    Verbeke, Francis
    JOURNAL OF HYPERTENSION, 2023, 41 : E88 - E88
  • [10] Predictive value of protein-bound uremic toxins for heart failure events in patients with chronic kidney disease
    Zwaenepoel, B. A. C.
    De Backer, T.
    Van Biesen, W.
    Glorieux, G.
    Verbeke, F.
    EUROPEAN JOURNAL OF HEART FAILURE, 2023, 25 : 83 - 83
12345