Control of respiration in flight muscle from the high-altitude bar-headed goose and low-altitude birds

被引:36
|
作者
Scott, Graham R. [1 ]
Richards, Jeffrey G. [1 ]
Milsom, William K. [1 ]
机构
[1] Univ British Columbia, Dept Zool, Vancouver, BC, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
high-altitude adaptation; hypoxia tolerance; mitochondrial metabolism; phylogenetically independent contrasts; physiological evolution; SKELETAL-MUSCLE; HYPOXIA TOLERANCE; FIBER CAPILLARIZATION; METABOLIC DEFENSE; CREATINE KINASES; MITOCHONDRIA; ADAPTATION; EXERCISE; HOMEOSTASIS; MECHANISMS;
D O I
10.1152/ajpregu.00241.2009
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Scott GR, Richards JG, Milsom WK. Control of respiration in flight muscle from the high-altitude bar-headed goose and low-altitude birds. Am J Physiol Regul Integr Comp Physiol 297: R1066-R1074, 2009. First published August 5, 2009; doi: 10.1152/ajpregu.00241.2009.-Barheaded geese fly at altitudes of up to 9,000 m on their biannual migration over the Himalayas. To determine whether the flight muscle of this species has evolved to facilitate exercise at high altitude, we compared the respiratory properties of permeabilized muscle fibers from bar-headed geese and several low-altitude waterfowl species. Respiratory capacities were assessed for maximal ADP stimulation (with single or multiple inputs to the electron transport system) and cytochrome oxidase excess capacity (with an exogenous electron donor) and were generally 20-40% higher in bar-headed geese when creatine was present. When respiration rates were extrapolated to the entire pectoral muscle mass, bar-headed geese had a higher mass-specific aerobic capacity. This may represent a surplus capacity that counteracts the depressive effects of hypoxia on mitochondrial respiration. However, there were no differences in activity for mitochondrial or glycolytic enzymes measured in homogenized muscle. The [ADP] leading to half-maximal stimulation (K(m)) was approximately twofold higher in bar-headed geese (10 vs. 4-6 mu M), and, while creatine reduced K(m) by 30% in this species, it had no effect on K(m) in low-altitude birds. Mitochondrial creatine kinase may therefore contribute to the regulation of oxidative phosphorylation in flight muscle of bar-headed geese, which could promote efficient coupling of ATP supply and demand. However, this was not based on differences in creatine kinase activity in isolated mitochondria or homogenized muscle. The unique differences in bar-headed geese existed without prior exercise or hypoxia exposure and were not a result of phylogenetic history, and may, therefore, be important evolutionary specializations for high-altitude flight.
引用
收藏
页码:R1066 / R1074
页数:9
相关论文
共 50 条
  • [41] Genetic polymorphisms in the renin-angiotensin system in high-altitude and low-altitude native American populations
    Rupert, JL
    Kidd, KK
    Norman, LE
    Monsalve, MV
    Hochachka, PW
    Devine, DV
    ANNALS OF HUMAN GENETICS, 2003, 67 : 17 - 25
  • [42] High-altitude and low-altitude adapted chicken gut-microbes have different functional diversity
    Bhagat, Neha Rani
    Chauhan, Priyanka
    Verma, Pratibha
    Mishra, Aradhana
    Bharti, Vijay K.
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [43] Hepatopulmonary syndrome is more common at low-altitude transplant centers than high-altitude centers.
    Trotter, JF
    Box, T
    Heneghan, M
    Shrestha, R
    HEPATOLOGY, 2001, 34 (04) : 544A - 544A
  • [44] CONTROL OF BREATHING IN SHERPAS AT LOW AND HIGH-ALTITUDE
    HACKETT, PH
    REEVES, JT
    REEVES, CD
    GROVER, RF
    RENNIE, D
    JOURNAL OF APPLIED PHYSIOLOGY, 1980, 49 (03) : 374 - 379
  • [45] Intraspecific functional differences of subalpine plant species growing in low-altitude microrefugia and high-altitude habitats
    Tonin, Rita
    Gerdol, Renato
    Wellstein, Camilla
    PLANT ECOLOGY, 2020, 221 (03) : 155 - 166
  • [46] Small non-coding RNA transcriptome of four high-altitude vertebrates and their low-altitude relatives
    Keren Long
    Siyuan Feng
    Jideng Ma
    Jinwei Zhang
    Long Jin
    Qianzi Tang
    Xun Wang
    Miaomiao Mai
    Weihang Xiao
    Lingyan Liu
    Xuewei Li
    Mingzhou Li
    Scientific Data, 6
  • [47] Intraspecific functional differences of subalpine plant species growing in low-altitude microrefugia and high-altitude habitats
    Rita Tonin
    Renato Gerdol
    Camilla Wellstein
    Plant Ecology, 2020, 221 : 155 - 166
  • [48] Optimal control of a low-altitude flight in the terrain-following mode
    Parshikov, A., V
    TRUDY INSTITUTA MATEMATIKI I MEKHANIKI URO RAN, 2020, 26 (02): : 225 - 237
  • [49] High-altitude and low-altitude adapted chicken gut-microbes have different functional diversity
    Neha Rani Bhagat
    Priyanka Chauhan
    Pratibha Verma
    Aradhana Mishra
    Vijay K. Bharti
    Scientific Reports, 13
  • [50] ALTERNATIVE ANALYSIS OF LOW-ALTITUDE AND HIGH-ALTITUDE OBSERVATIONS OF RING CURRENT IONS DURING A STORM RECOVERY PHASE
    LYONS, LR
    JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS, 1977, 82 (16): : 2367 - 2370