Trace-level sensing of dopamine in real samples using molecularly imprinted polymer-sensor

被引：30

作者：

Prasad, Bhim Bali ^{[1
]}

Srivastava, Shrinkhala ^{[1
]}

Tiwari, Khushaboo ^{[1
]}

Sharma, Piyush Sindhu ^{[1
]}

机构：

[1] Banaras Hindu Univ, Dept Chem, Analyt Div, Fac Sci, Varanasi 221005, Uttar Pradesh, India

来源：

BIOCHEMICAL ENGINEERING JOURNAL | 2009年 / 44卷 / 2-3期

关键词：

Bioseparations; Membrane; Mass-transfer; Affinity; Dopamine; Molecularly imprinted polymer; FILM-MODIFIED ELECTRODE; MERCURY DROP ELECTRODE; ASCORBIC-ACID; URIC-ACID; NANOPARTICLES; RECOGNITION; CATECHOLAMINES; EXTRACTION; GEL;

D O I：

10.1016/j.bej.2008.12.013

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Induced-fit responsive dopamine (DA) imprinted polymer, poly (melamine-co-chloranil). was used as a suitable coating material for the modification of a hanging mercury drop electrode. The zwitterionic conformation of the imprinted polymer responded differential pulse, cathodic stripping voltammetric current, without any false-positive or false-negative contributions of non-specific sorptions, in aqueous environment of complex matrices. The limit of detection (3 sigma) of dopamine was found to be as low as 0.148 ng mL(-1). by the proposed sensor that could be considered a sensitive marker of dopamine depletion in Parkinson's disease (PD). (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：232 / 239

页数：8

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