Bevacizumab combined with gemcitabine and capecitabine for advanced pancreatic cancer: a phase II study

被引：28
|
作者：
Javle, M. [1 ]
Yu, J. [2 ]
Garrett, C. [3 ]
Pande, A. [1 ]
Kuvshinoff, B. [4 ]
Litwin, A. [5 ]
Phelan, J., III [6 ]
Gibbs, J. [4 ]
Iyer, R. [1 ]
机构：
[1] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA
[2] Roswell Pk Canc Inst, Dept Biostat, Buffalo, NY 14263 USA
[3] H Lee Moffitt Canc Inst, Dept Med Oncol, Tampa, FL 33612 USA
[4] Roswell Pk Canc Inst, Dept Surg, Buffalo, NY 14263 USA
[5] Roswell Pk Canc Inst, Dept Radiol, Buffalo, NY 14263 USA
[6] Lipson Canc Ctr, Dept Oncol, Rochester, NY 14621 USA
来源：
BRITISH JOURNAL OF CANCER | 2009年 / 100卷 / 12期
关键词：
gemcitabine; capecitabine; bevacizumab; pancreatic cancer; chemotherapy; metastatic; ENDOTHELIAL GROWTH-FACTOR; TRIAL; COMBINATION; SURVIVAL; VEGF; ANGIOGENESIS; CHEMOTHERAPY;
D O I：
10.1038/sj.bjc.6605099
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A total of 50 patients with advanced pancreatic cancer were enrolled in a phase II study of bevacizumab 15 mg kg(-1), capecitabine 1300 mg m(-2) daily for 2 weeks and gemcitabine 1000 mg m(-2) weekly 2 times; cycles were repeated every 21 days. Radiological response rate was 22%; progression-free survival and over survival were 5.8 and 9.8 months respectively. Grade 3 or 4 toxicities included neutropaenia (22%), thrombocytopaenia (14%), thromboembolic events (12%), hypertension (8%) and haemorrhage (6%). British Journal of Cancer (2009) 100, 1842-1845. doi: 10.1038/sj.bjc.6605099 www.bjcancer.com Published online 2 June 2009 (C) 2009 Cancer Research UK
引用
收藏
页码：1842 / 1845
页数：4
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