The neurobiological correlates of childhood adversity and implications for treatment

被引：95

作者：

Tyrka, A. R. ^{[1
,2
,3
]}

Burgers, D. E. ^{[1
,2
]}

Philip, N. S. ^{[1
,2
,3
]}

Price, L. H. ^{[1
,2
,3
]}

Carpenter, L. L. ^{[1
,2
,3
]}

机构：

[1] Butler Hosp, Mood Disorders Res Program, Providence, RI 02906 USA

[2] Butler Hosp, Lab Clin & Translat Neurosci, Providence, RI 02906 USA

[3] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, Providence, RI 02912 USA

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2013年 / 128卷 / 06期

关键词：

early-life stress; childhood abuse; neurobiology; treatment; POSTTRAUMATIC-STRESS-DISORDER; DIALECTICAL BEHAVIOR-THERAPY; MAJOR DEPRESSIVE DISORDER; PITUITARY-ADRENAL AXIS; EARLY-LIFE STRESS; NEUROTROPHIC FACTOR; GLUCOCORTICOID-RECEPTOR; ADJUNCTIVE THERAPY; METABOLIC SYNDROME; ANXIETY DISORDERS;

D O I：

10.1111/acps.12143

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

ObjectiveThis article provides an overview of research on the neurobiological correlates of childhood adversity and a selective review of treatment implications. MethodFindings from a broad array of human and animal studies of early adversity were reviewed. ResultsTopics reviewed include neuroendocrine, neurotrophic, neuroimaging, and cognitive effects of adversity, as well as genetic and epigenetic influences. Effects of early-life stress on treatment outcome are considered, and development of treatments designed to address the neurobiological abnormalities is discussed. ConclusionEarly adversity is associated with abnormalities of several neurobiological systems that are implicated in the development of psychopathology and other medical conditions. Early-life stress negatively impacts treatment outcome, and individuals may require treatments that are specific to this condition.

引用

页码：434 / 447

页数：14

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