Lewis acid-promoted addition of methylenecyclopropanes to aldehydes and ketones

被引：23
|
作者：
Miura, K [1 ]
Takasumi, M [1 ]
Hondo, T [1 ]
Saito, H [1 ]
Hosomi, A [1 ]
机构：
[1] UNIV TSUKUBA,DEPT CHEM,TSUKUBA,IBARAKI 305,JAPAN
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 26期
关键词：
D O I：
10.1016/S0040-4039(97)00981-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the presence of TiCl4, methylenecyclopropane (1a) easily reacted with aliphatic aldehydes to give the beta-(chloromethyl)allylated products 2 in good yields along with a small amount of the methylenetetrahydrofurans 3. The reaction with chiral alpha- and beta-alkoxy aldehydes proceeded with high levels of chelation control. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：4587 / 4590
页数：4
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