A Novel Candidate for Prevention and Treatment of Atherosclerosis: Urolithin B Decreases Lipid Plaque Deposition in apoE-/- Mice and Increases Early Stages of Reverse Cholesterol Transport in ox-LDL Treated Macrophages Cells

被引：41

作者：

Zhao, Wenhua ^{[1
]}

Wang, Lixue ^{[1
]}

Haller, Viktoria ^{[2
]}

Ritsch, Andreas ^{[2
]}

机构：

[1] Capital Med Univ, Coll Pharmaceut Sci, 10 Xitoutiao, Beijing 100069, Peoples R China

[2] Med Univ Innsbruck, Dept Internal Med 1, Anichstr 35, A-6020 Innsbruck, Austria

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2019年 / 63卷 / 10期

基金：

美国国家科学基金会; 奥地利科学基金会;

关键词：

atherosclerosis; cholesterol efflux; reverse cholesterol transport; urolithin B; urolithin B sulfate; HIGH-DENSITY-LIPOPROTEIN; RECEPTOR CLASS-B; I SR-BI; SCAVENGER RECEPTOR; EFFLUX CAPACITY; HDL-CHOLESTEROL; DIETARY POLYPHENOLS; ABCA1; METABOLITES; DISEASE;

D O I：

10.1002/mnfr.201800887

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Scope: HDL cholesterol is inversely related to the incidence of atherosclerosis. Polyphenols including ellagitannins have been shown to exert antiatherogenic properties. Urolithin B is formed from ellagitannins by components of the gut microbiota, and urolithins might be involved in beneficial effects against cardiovascular diseases in vitro. In this study, the influence of urolithin B on several parameters involved in the lipid plaque deposition and the reverse cholesterol transport is investigated. Methods and results: In apoE(-/-) mice and two different macrophage cell lines, the influence of urolithin B and its phase II conjugated metabolite on lipid plaque deposition, cholesterol uptake, and expression of ABCA1 and SR-BI is tested. It is shown that urolithin B decreases lipid plaque deposition, both urolithin B and urolithin B sulfate modulate expression of SR-BI and ABCA1, and cholesterol efflux increases from cholesterol laden macrophages to HDL particles as well as to reverse lipid uptake by stimulated THP-1 macrophages. Conclusions: Urolithin B can decrease lipid plaque deposition, and urolithin B and urolithin B sulfate are able to induce reverse cholesterol transport by influencing expression of key proteins of this pathway. Urolithin B may represent the basis for development of new drugs for prevention and treatment of atherosclerosis in humans.

引用

页数：9