Apparent bicarbonate space in children

被引:4
|
作者
Repetto, Horacio A. [1 ]
Penna, Roberto
机构
[1] Hosp Nacl Prof A Posadas, Serv Pediat, Buenos Aires, DF, Argentina
[2] Hosp Nacl Prof A Posadas, Intens Care Unit, Buenos Aires, DF, Argentina
[3] Univ Buenos Aires, Fac Med, Dept Pediat, RA-1053 Buenos Aires, DF, Argentina
来源
关键词
bicarbonate (HCO3-); bicarbonate space; metabolic acidosis; correction; buffer mechanisms; acidosis treatment; children acid-base derangements;
D O I
10.1100/tsw.2006.32
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The amount needed to change the concentration of a solute requires the knowledge of its volume of distribution in the solution. Electrolytes that do not participate in active metabolic reactions have a fixed volume of distribution that corresponds to the volume of water in which they solubilize. Bicarbonate infusion is used to correct hyperchloremic metabolic acidosis. Its volume of distribution (bicarbonate space) changes with its participation in the blood buffer systems. In other words, it is not a fixed physical volume, like that of other solutes. In this paper, we shall review experimental studies that supported evidence for this knowledge and analyze the basic hypothesis to explain the phenomena. Since we have not found clinical studies in children, we shall report our experience in a group of patients with metabolic acidosis treated with bicarbonate infusion in whom apparent bicarbonate space was measured and compared with data in adults from the literature. Guidelines for amount of bicarbonate needed to increase its concentration according to baseline bicarbonate concentration will be suggested.
引用
收藏
页码:148 / 153
页数:6
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