CT screening for lung cancer

The National Lung Screening Trial (NLST), a randomized, controlled trial, is the most expensive screening study ever proposed. It compares CT screening with chest radiograph screening, and its designers envision that it will provide an answer about the benefit of CT screening in about 10 years. This article raises the general level of concern about the underpinnings of such randomized screening trials, and conveys some of the evidence that led to pessimism about the NLST.