Pyoderma gangrenosum: successful treatment with locally applied cyclosporine A

Pyoderma gangrenosum (PG) is a rare, ulcerative skin disease, probably caused by vasculitic processes. In 20 to 70% of cases, it is associated with an underlying disease, most commonly inflammatory bowel disease, rheumatological or haematological disease. Additionally, PG occurs in connection with traumatic events. The majority of the numerous concepts known to treat pyoderma gangrenosum include systemic application of immunosuppressants. We report on a two year experience in the treatment of PG with locally applied cyclosporine A solution.