Synthesis of Novel Ursolic Acid Derivatives

To investigate anti-tumor structure-activity relation-(10 novel compounds) were designed and synthesized. They ship of derivatives of ursolic acid and obtain more effective anti-might provide a powerful incentive for further research on the tumor compounds, 12 ursolic acid derivatives (10 novel chemical modifications and structure-activity relationships of compounds) with modified structures at the C-3 and C-28 ursolic acid. position were synthesized. The structures of all compounds were confirmed by ESI-MS, IR and H-1-NMR spectral date.