Haloperidol;
Olanzapine;
Terminal delirium;
Home hospice;
Palliative care;
End of life;
MANAGEMENT;
CANCER;
SEDATION;
SCALE;
END;
D O I:
10.1186/s13063-022-06238-4
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Background: The phenomenon of restlessness, agitation, or cognitive disturbances experienced by dying patients is well-known in palliative care; more than half of these patients will experience delirium symptoms at end-of-life. When not identified early and effectively managed, delirium symptoms could lead to caregiver and patient distress and harm. Methods: Eighty patients with a prognosis of 7 days or less will be recruited for an open-label randomised control trial. The two arms compare oral-transmucosal haloperidol 2.5 mg vs olanzapine 5 mg over 72 h. The severity of agitation, delirium and toxicities of treatments will be compared at the 24th, 48th and 72nd hour after drug administration. Discussion: This trial is the first to compare anti-psychotics in the management of delirium at the dying stage in the home hospice setting using the oral transmucosal route. Ethical considerations, as well as recruitment procedures, are discussed.
机构:
La Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, ItalyLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy
Mercadante, S.
Radbruch, L.
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机构:
Univ Klinikum Aachen, RWTH Aachen, Klin Palliativmed, Aachen, GermanyLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy
Radbruch, L.
Davies, A.
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机构:
Royal Marsden Hosp, Dept Palliat Med, Sutton, Surrey, EnglandLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy
Davies, A.
Poulain, P.
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机构:
Inst Claudius Regaud, Toulouse & Polyclin Ormeau, Tarbes, FranceLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy
Poulain, P.
Sitte, T.
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机构:
Schmerz & PalliativZentrum Fulda & PalliativNetz, Fulda, GermanyLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy
Sitte, T.
Perkins, P.
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机构:
Sue Ryder Care Leckhampton Court Hospice, Cheltenham, Glos, England
Gloucestershire Hosp NHS Fdn Trust, Cheltenham, Glos, EnglandLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy
Perkins, P.
Colberg, T.
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机构:
Nycomed, Res & Dev, Roskilde, DenmarkLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy
Colberg, T.
Camba, M. A.
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机构:
Anesthesiol Serv, Unidad Dolor, La Coruna, SpainLa Maddalena, Casa Cura Ad Alta Specialita Pain Relief & Pallia, Dipartimento Oncol, I-90146 Palermo, Italy