Toward the total synthesis of Scleritodermin A:: preparation of the C1-N15 fragment

被引：22

作者：

Sellanes, Diver ^{[1
]}

Manta, Eduardo ^{[1
]}

Serra, Gloria ^{[1
]}

机构：

[1] UDELAR, Catedra Quim Farmaceut, Dept Quim Organ, Fac Quim, Montevideo, Uruguay

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 10期

关键词：

Scleritodermin A; thiazole; alpha-ketoamide; Wittig;

D O I：

10.1016/j.tetlet.2007.01.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the C-1-N-15 fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the alpha-keto amide linkage by the use of a highly activated alpha,beta-ketonitrile. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1827 / 1830

页数：4

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