The role of the macrophage in periprosthetic bone loss

被引：0
|
作者：
Santerre, JP
Labow, RS
Boynton, EL
机构：
[1] Univ Toronto, Inst Biomed Biomat Engn, Toronto, ON, Canada
[2] Univ Ottawa, Inst Heart, Dept Surg, Ottawa, ON, Canada
[3] Univ Toronto, Mt Sinai Hosp, Dept Surg, Div Orthopaed, Toronto, ON, Canada
来源：
CANADIAN JOURNAL OF SURGERY | 2000年 / 43卷 / 03期
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D O I：
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中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Aseptic loosening after total joint replacement remains the most common reason for long-term implant failure, Macrophages activated by submicron wear particles of the polyethylene liner used in joint replacement have been shown to be the source of periprosthetic bone loss. Understanding the role of material chemistry in macrophage activation and the subsequent effects that macrophage-derived enzymes play in the degradation of implanted biomaterials is key to developing methods for prolonging the lifespan of implantable materials.
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页码：173 / 179
页数：7
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