Double Functionalized Nanoporous Magnetic Gadolinium-Silica Composite for Doxorubicin Delivery

被引：12
|
作者：
Mehrani, Atousa [1 ]
Ahmadvand, Parvaneh [1 ]
Barforushi, Maryam Mehdizadeh [2 ]
Mehrani, Kheirollah [1 ]
机构：
[1] Islamic Azad Univ, Dept Chem, Sci & Res Branch, Tehran, Iran
[2] Islamic Azad Univ, Fac Pharmaceut Chem, Dept Nanochem, Pharmaceut Sci Branch, Tehran, Iran
来源：
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2016年 / 26卷 / 01期
基金：
美国国家科学基金会;
关键词：
Drug delivery; Doxorubicin; Magnetic drug carrier; Nanoporous gadolinium; DRUG-DELIVERY; MESOPOROUS SILICA; CONTROLLED-RELEASE; ORAL DELIVERY; NANOPARTICLES; CARRIERS; SYSTEM; CLARITHROMYCIN; NANOCOMPOSITES; NANOCARRIERS;
D O I：
10.1007/s10904-015-0302-6
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this paper, a novel magnetic carrier has been developed based on silica and gadolinium composite. The synthesized carrier has porous structure and can be simply modified with different functional groups using silane coupling agents. The formation of this novel carrier was confirmed by different analytical methods including FT-IR, X-ray powder diffraction, TEM microscopy, Single point BET, Thermal analysis, EDAX, and elemental analysis. The synthesized carrier was applied for doxorubicin delivery as a common anti-cancer drug. The results showed high drug uptake and controlled release using this carrier. Last but not least, this carrier has higher release rate in acidic solutions in comparison to neutral pH which is beneficial for cancer therapy since the cancer cells are slightly acidic.
引用
收藏
页码：226 / 232
页数：7
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