Metal-free annulation of β-acylamino ketones: facile access to spirooxazolines and oxazolines via oxidative C-O bond formation

被引：23

作者：

Chavan, Santosh S. ^{[1
]}

Rupanawar, Bapurao D. ^{[1
]}

Kamble, Rohit B. ^{[1
]}

Shelke, Anil M. ^{[1
]}

Suryavanshi, Gurunath ^{[1
]}

机构：

[1] CSIR, Chem Engn & Proc Dev Div, Natl Chem Lab, Dr Homi Bhaba Rd, Pune 411008, Maharashtra, India

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 04期

关键词：

ONE-POT SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; CYCLIZATION; EFFICIENT; NITRILES; ESTERS; CONVERSION; CHEMISTRY; CATALYSIS; ALDEHYDES;

D O I：

10.1039/c7qo00783c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free annulation reaction of beta-acylamino ketone derivatives has been reported for the synthesis of a group of functionalized spirooxazolines and oxazolines in good to excellent yields. The reaction proceeds via phenyliodine(III) diacetate (PIDA)-mediated oxidative C-O bond formation in the presence of BF3-OEt2. The mild reaction conditions, broad substrate scope, simple execution and synthetic potential of the products make this novel protocol very attractive.

引用

页码：544 / 548

页数：5

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