Formation of new C-O and C-N bonds via base promoted Csp2-Csp3 bond cleavage of α-nitro ketone

被引：15
|
作者：
Sarma, Manas Jyoti [1 ]
Borah, Arun Jyoti [1 ]
Rajbongshi, Kamal Krishna [1 ]
Phukan, Prodeep [1 ]
机构：
[1] Gauhati Univ, Dept Chem, Gauhati 781014, Assam, India
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 50期
关键词：
C-C cleavage; alpha-Nitroketone; Bromamine-T; Esters; Amide; ACID METHYL-ESTER; ENANTIOSELECTIVE SYNTHESIS; METAL-FREE; ASYMMETRIC AMINOHYDROXYLATION; OXIDATIVE CLEAVAGE; MOLECULAR-OXYGEN; BROMAMINE-T; CARBON; ANTIBACTERIAL; ACTIVATION;
D O I：
10.1016/j.tetlet.2015.11.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalyst free protocol has been developed for nucleophilic C-sp2 C-sp3 bond cleavage of alpha-nitroketone in the presence of potassium carbonate to create new C-O and C-N bonds. A series of different substituted alpha-nitroketones could be selectively cleaved and converted into corresponding esters and tosylamides in the presence of alcohols and bromamine-T, respectively. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7008 / 7011
页数：4
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