Antiproliferative Triterpenoid Saponins from the Stem of Psychotria sp.

被引：12

作者：

Zhang, Cui-Xian ^{[1
]}

Zhang, Dong-Mei ^{[2
]}

Chen, Min-Feng ^{[2
]}

Guan, Shan-Yue ^{[3
]}

Yao, Jun-Hua ^{[3
]}

He, Xi-Xin ^{[1
]}

Lei, Ling-Fang ^{[1
]}

Zhong, Ying ^{[1
]}

Wang, Zhi-Fang ^{[1
]}

Ye, Wen-Cai ^{[2
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Chinese Mat Med, Guangzhou 510006, Guangdong, Peoples R China

[2] Jinan Univ, Coll Pharm, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Instrumental Anal & Res Ctr, Guangzhou 510275, Guangdong, Peoples R China

来源：

PLANTA MEDICA | 2013年 / 79卷 / 11期

基金：

美国国家科学基金会;

关键词：

Rubiaceae; Psychotria sp; triterpenoid saponins; antiproliferative; PYRROLIDINOINDOLINE ALKALOIDS;

D O I：

10.1055/s-0032-1328650

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new triterpenoid saponins, psychotrianosides A-F (1-6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1-8 against five human cancer cell lines (MDA-MB-231, MCF-7, MCF-7/ADM, HepG2, and HepG2/ADM) are reported for the first time. Psychotrianoside C (3) showed the most potent antiproliferative activity among these saponins, and the IC50 value of 3 against MDA-MB-231 was 2.391 +/- 0.161 mu M. Compound 3 was also found to induce apoptosis.

引用

页码：978 / 986

页数：9

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