The Evolution and Future of CAR T Cells for B-Cell Acute Lymphoblastic Leukemia

被引：31
|
作者：
Annesley, Colleen E. [1 ]
Summers, Corinne [1 ]
Ceppi, Francesco [1 ]
Gardner, Rebecca A. [1 ]
机构：
[1] Seattle Childrens Hosp, Seattle, WA 98105 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2018年 / 103卷 / 04期
关键词：
CHIMERIC ANTIGEN RECEPTORS; CYTOKINE RELEASE SYNDROME; SUSTAINED REMISSIONS; CD19; THERAPY; CD8(+); CHILDREN; PERSISTENCE; MEMORY; CHAIN;
D O I：
10.1002/cpt.950
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Several CAR T designs with CD19 specificity have been associated with consistent responses in clinical trials with complete remission (CR) rates ranging from 70-90%. Relevant challenges remain to be addressed, such as production time, early loss of CAR T cells, relapse due to loss of the target antigen, and prevention of severe cytokine release syndrome and neurotoxicity. This review describes constructs, clinical trial results, side effects, and future direction of CAR T-cell therapy in B-ALL.
引用
收藏
页码：591 / 598
页数：8
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