Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop

被引：142

作者：

Zlokovic, Berislav, V ^{[1
]}

Gottesman, Rebecca F. ^{[2
]}

Bernstein, Kenneth E. ^{[3
]}

Seshadri, Sudha ^{[4
,5
]}

McKee, Ann ^{[6
,7
]}

Snyder, Heather ^{[8
]}

Greenberg, Steven M. ^{[9
,10
]}

Yaffe, Kristine ^{[11
]}

Schaffer, Chris B. ^{[12
]}

Yuan, Chun ^{[13
]}

Hughes, Timothy M. ^{[14
]}

Daemen, Mat J. ^{[15
]}

Williamson, Jeff D. ^{[14
]}

Gonzalez, Hector M. ^{[16
]}

Schneider, Julie ^{[17
]}

Wellington, Cheryl L. ^{[18
,19
]}

Katusic, Zvonimir S. ^{[20
]}

Stoeckel, Luke ^{[21
]}

Anderson, Dallas

Koenig, James, I ^{[22
]}

Corriveau, Roderick A. ^{[22
]}

Fine, Lawrence ^{[23
]}

Galis, Zorina S. ^{[23
]}

Reis, Jared ^{[23
]}

Wright, Jacqueline D. ^{[23
]}

Chen, Jue ^{[23
]}

机构：

[1] Univ Southern Calif, Los Angeles, CA 90007 USA

[2] Johns Hopkins Univ, Baltimore, MD USA

[3] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[5] Boston Univ, San Antonio, TX USA

[6] VA Boston Healthcare Syst, Boston, MA USA

[7] Boston Univ, Boston, MA 02215 USA

[8] Alzheimers Assoc, Chicago, IL USA

[9] Massachusetts Gen Hosp, Boston, MA 02114 USA

[10] Harvard Med Sch, Boston, MA 02115 USA

[11] Univ Calif San Francisco, San Francisco, CA 94143 USA

[12] Cornell Univ, Ithaca, NY USA

[13] Univ Washington, Seattle, WA 98195 USA

[14] Wake Forest Sch Med, Winston Salem, NC 27101 USA

[15] Univ Amsterdam, Amsterdam UMC, Amsterdam, Netherlands

[16] Univ Calif San Diego, La Jolla, CA 92093 USA

[17] Rush Univ, Chicago, IL 60612 USA

[18] Univ British Columbia, Vancouver, BC, Canada

[19] Univ British Columbia, Kelowna, BC, Canada

[20] Mayo Clin, Rochester, MN USA

[21] NIA, Bethesda, MD 20892 USA

[22] NINDS, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[23] NHLBI, Bethesda, MD 20817 USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease-related dementias; cerebrovascular and cardiovascular disease; vascular contributions to cognitive impairment and dementia; CARDIOVASCULAR RISK-FACTORS; ENDOTHELIAL NITRIC-OXIDE; BETA-AMYLOID DEPOSITION; ANGIOTENSIN-CONVERTING ENZYME; BRAIN-BARRIER PERMEABILITY; BODY-MASS INDEX; ALZHEIMERS-DISEASE; LATE-LIFE; DECADES; ATHEROSCLEROSIS RISK;

D O I：

10.1002/alz.12157

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.

引用

页码：1714 / 1733

页数：20

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