Borrelia burgdorferi uridine kinase: An enzyme of the pyrimidine salvage pathway for endogenous use of nucleotides

被引：0
|
作者：
BoursauxEude, C
Margarita, D
Gilles, AM
Barzu, O
SaintGirons, I
机构：
[1] INST PASTEUR,UNITE BACTERIOL MOL & MED,F-75724 PARIS 15,FRANCE
[2] INST PASTEUR,UNITE BIOCHIM REGULAT CELLULAIRES,F-75724 PARIS 15,FRANCE
来源：
FEMS MICROBIOLOGY LETTERS | 1997年 / 151卷 / 02期
关键词：
Borrelia burgdorferi; udk; telomere; pyrimidine;
D O I：
10.1016/S0378-1097(97)00171-7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The 621 bp udk gene encoding Borrelia burgdorferi potential uridine kinase, involved in the pyrimidine salvage pathway, was cloned and sequenced. The B. burgdorferi protein has a molecular mass of 24 kDa in sodium dodecyl sulfate-polyacrylamide gel. The N-terminal sequence of the protein, Ala-Lys-Ile-Ile, is identical to that predicted but lacks N-terminal methionine. udk is located at around 15 kb from the left telomere and forms an operon with an upstream ORF. A likely hypothesis for the role of the pyrimidine salvage pathway is the sole use of endogenous nucleotides for Borrelia.
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页码：257 / 261
页数：5
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