Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

被引：16
|
作者：
Fu, Ying-Kai [1 ,2 ]
Chang, Chia-Jung
Chen, Kuan-Yin
Hwang, Li-Chung
Wu, Kuo-Hung
Chang, Kang-Wei
Jan, Meei-Ling
Chen, Chia-Chieh
Chang, Chih-Hsien
机构：
[1] Inst Nucl Energy Res, Atom Energy Council, Tao Yuan 32546, Taiwan
[2] Chung Yuan Christian Univ, Dept Chem, Chungli 32023, Taiwan
来源：
APPLIED RADIATION AND ISOTOPES | 2009年 / 67卷 / 10期
关键词：
F-18-FDG; MicroPET; Rat ischemia model; TRAUMATIC BRAIN-INJURY; POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; OCCLUSION; RECOVERY; PET;
D O I：
10.1016/j.apradiso.2009.03.002
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that F-18-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with F-18-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents. (C) 2009 Elsevier Ltd. All rights reserved,
引用
收藏
页码：1743 / 1747
页数：5
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