Effect of childhood physical abuse on social anxiety is mediated via reduced frontal lobe and amygdala-hippocampus complex volume in adult clinical high-risk subjects

被引：13

作者：

Salokangas, R. K. R. ^{[1
]}

Hietala, J. ^{[1
]}

Armio, R. L. ^{[1
]}

Laurikainen, H. ^{[1
]}

From, T. ^{[1
]}

Borgwardt, S. ^{[2
]}

Riecher-Rossler, A. ^{[2
]}

Brambilla, P. ^{[3
]}

Bonivento, C. ^{[4
]}

Meisenzahl, E. ^{[5
]}

Schultze-Lutter, F. ^{[5
]}

Haidl, T. ^{[6
]}

Ruhrmann, S. ^{[6
]}

Upthegrove, R. ^{[7
]}

Wood, S. J. ^{[7
,8
,9
]}

Pantelis, C. ^{[10
,11
]}

Kambeitz-Ilankovic, L. ^{[12
]}

Ruef, A. ^{[12
]}

Dwyer, D. B. ^{[12
]}

Kambeitz, J. ^{[6
]}

Koutsouleris, N. ^{[12
]}

机构：

[1] Univ Turku, Dept Psychiat, Turku, Finland

[2] Univ Basel, Dept Psychiat, UPK, Psychiat Univ Hosp, Basel, Switzerland

[3] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Neurosci & Mental Hlth, Milan, Italy

[4] Univ Udine, Dept Med Area, Udine, Italy

[5] Heinrich Heine Univ, Med Fac, Dept Psychiat & Psychotherapy, Dusseldorf, Germany

[6] Univ Cologne, Dept Psychiat & Psychotherapy, Cologne, Germany

[7] Univ Birmingham, Inst Mental Hlth, Birmingham, W Midlands, England

[8] Orygen, Natl Ctr Excellence Youth Mental Hlth, Melbourne, Vic, Australia

[9] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia

[10] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia

[11] Melbourne Hlth, Melbourne, Vic, Australia

[12] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Munich, Germany

来源：

SCHIZOPHRENIA RESEARCH | 2021年 / 227卷

关键词：

Physical abuse; Brain MRI scan; Amygdala-hippocampus complex; Psychosis; High-risk; Social anxiety;

D O I：

10.1016/j.schres.2020.05.041

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Childhood adverse experiences (CAE) are associated with clinical psychiatric disorders and symptoms, and with volumetric abnormalities in the amygdala-hippocampus complex (AmHiC) and frontal lobe (FroL) in adulthood. Aim: To study whether CAE are associated with reduced AmHiC and FroL and whether these structures mediate the effect of CAE on social anxiety and depression. Method: In seven European centres, 374 patients with recent onset of psychosis (n = 127), clinical high-risk to psychosis (n = 119) or recent onset of depression (n = 128) were scanned with MRI and their FroL and AmHiC volumes were measured. They all completed self-report scales for assessment of CAE, social anxiety and depression. Results: Of the CAE domains, physical abuse was associated specifically with reduced grey and white matter volumes of FroL and AmHiC in psychotic and high-risk patients. After controlling intracranial volume, PhyAb associated significantly with FroL and its grey matter volume in high-risk patients only. In mediation analyses, the effect of physical abuse on social anxiety was mediated via reduced FroL grey mater volume in high-risk patients. In them, when the effects of AmHiC and depression were controlled, the effect of physical abuse on social anxiety was mediated via FroL grey matter volume reduction. Conclusions: Childhood physical abuse is associated with reduced frontal lobe and amygdala-hippocampus complex volume in adult subjects with psychotic symptoms. Reduced frontal lobe and amygdala-hippocampus complex volume mediate the effect of physical abuse on social anxiety in high-risk patients. The effect of physical abuse on depression-independent social anxiety is mediated via reduced frontal lobe. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：101 / 109

页数：9