Effect of Ultrasound-guided Hyaluronic Acid Filler Injection in Anophthalmic Enophthalmos Syndrome

Purpose: To evaluate the outcomes of ultrasound-guided hyaluronic acid filler injection in anophthalmic enophthalmos syndrome patients. Methods: We retrospectively reviewed the clinical records of 14 patients who were diagnosed with anophthalmic enophthalmos syndrome and treated with ultrasound-guided hyaluronic acid filler injection from October 2011 to September 2017. Filler was injected transcutaneous in the retrobulbar area or eyelid under ultrasound guidance and improvement of superior deep sulcus and patient satisfaction after three months of injection were evaluated. Results: The mean number of injections was 1.2 +/- 0.4, and 1.14 +/- 0.30 mL of hyaluronic acid filler was used for each injection. There was a significant decrease in mean superior deep sulcus grade from 3.06 +/- 0.90 before injection to 0.20 +/- 0.56 after injection. Patient satisfaction was higher in the severe superior deep sulcus before injection group who showed greater superior deep sulcus improvement. Conclusions: Hyaluronic acid filler injections for patients with anophthalmic enophthalmos syndrome were easy to perform in the outpatient department and showed excellent outcomes. The more severe the enophthalmos, the higher the satisfaction after injection, which showed that hyaluronic acid filler injection was an effective treatment for patients with severe enophthalmos syndrome.