Lipase-catalyzed hydrolysis of 2-(4-hydroxyphenyl)propionic acid ethyl ester to (R)-(-)-2-(4-hydroxyphenyl)propanoic acid

被引：3
|
作者：
Yuan, Xin [1 ]
Zhang, Panliang [1 ]
Liu, Guangyong [1 ]
Xu, Weifeng [1 ]
Tang, Kewen [1 ]
机构：
[1] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Hunan, Peoples R China
来源：
CHEMICAL PAPERS | 2019年 / 73卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Kinetic resolution; Lipase AK; Hydrolysis; 2-(4-Hydroxyphenyl) propionic acid ethyl ester; ENANTIOSELECTIVE HYDROLYSIS; SEPARATION; IMMOBILIZATION; PERFORMANCE; KETOPROFEN; RESOLUTION; EFFICIENT; NAPROXEN;
D O I：
10.1007/s11696-019-00796-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Stereoselective hydrolysis of (+/-)-2-(4-hydroxyphenyl)propionic acid ethyl ester (2-HPPAEE) by lipase catalyzed in aqueous system was investigated. Lipase AK with higher catalytic activity and enantioselectivity was selected as catalyst. Simultaneously, factors affecting the conversion of substrate (c) and the enantiomeric excess of product (ee(p)) were optimized. The optimal conditions were established, involving 45 degrees C of temperature, 5.5 of pH, 10mg of lipase AK dosage, 0.04mmol of substrate dosage and 40h of reaction time. Under the optimum conditions, c and ee(p) could reach up to 49% and 98%, respectively.
引用
收藏
页码：2461 / 2468
页数：8
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