Dystroglycan depletion inhibits the functions of differentiated HL-60 cells

被引：4

作者：

Martinez-Zarate, Alma Delia ^{[1
]}

Martinez-Vieyra, Ivette ^{[1
]}

Alonso-Rangel, Lea ^{[1
]}

Cisneros, Bulmaro ^{[2
]}

Winder, Steve J. ^{[3
]}

Cerecedo, Doris ^{[1
]}

机构：

[1] IPN, Escuela Nacl Med & Homeopatia, Lab Hematobiol, Mexico City 07320, DF, Mexico

[2] Cinvestav IPN, Ctr Invest Estud Avanzados, Dept Genet & Biol Mol, Mexico City 07320, DF, Mexico

[3] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2014年 / 448卷 / 03期

关键词：

Dystroglycan; HL-60; cells; Differentiation; Phagocytosis; Respiratory burst activity; Migration; ACTIN POLYMERIZATION; HUMAN NEUTROPHILS; DYSTROPHIN; ADHESION; CHEMOTAXIS; EXPRESSION; FILOPODIA; PROMOTES; LINE;

D O I：

10.1016/j.bbrc.2014.04.110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dystroglycan has recently been characterized in blood tissue cells, as part of the dystrophin glycoprotein complex but to date nothing is known of its role in the differentiation process of neutrophils. We have investigated the role of dystroglycan in the human promyelocytic leukemic cell line HL-60 differentiated to neutrophils. Depletion of dystroglycan by RNAi resulted in altered morphology and reduced properties of differentiated HL-60 cells, including chemotaxis, respiratory burst, phagocytic activities and expression of markers of differentiation. These findings strongly implicate dystroglycan as a key membrane adhesion protein involved in the differentiation process in HL-60 cells. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：274 / 280

页数：7

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