Asymmetric reduction of acetophenone over heterogeneous oxazaborolidine catalysts

被引：14
|
作者：
Molvinger, K
Lopez, M
Court, J
机构：
[1] CNRS, UMR 5616, LEDSS, F-38041 Grenoble, France
[2] Univ Grenoble 1, F-38041 Grenoble, France
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 11期
关键词：
D O I：
10.1016/S0957-4166(00)00191-9
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The reduction of acetophenone over the heterogeneous catalyst NiB2-0.1 (oxazaborolidine)(0.1) by borane in THF at 273 K is quicker than in homogeneous phase. The catalyst presented high enantioselectivity (ee greater than or equal to 90%) at low molar ratio provided the ketone was added very slowly to the catalyst and borane complex. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2263 / 2266
页数：4
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