Genetic and Epigenetic Underpinnings of Eosinophilic Esophagitis

被引：30
|
作者：
Sherrill, Joseph D. [1 ]
Rothenberg, Marc E. [1 ]
机构：
[1] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Div Allergy & Immunol,Dept Pediat, Cincinnati, OH 45229 USA
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 02期
关键词：
Genetic variant; Thymic stromal lymphopoietin; Eotaxin-3; Epigenetics; MicroRNA; THYMIC STROMAL LYMPHOPOIETIN; AIRWAY INFLAMMATION; EPITHELIAL-CELLS; ALLERGIC LUNG; EXPRESSION; PERIOSTIN; IL-13; EOTAXIN-3; ASSOCIATE; VARIANTS;
D O I：
10.1016/j.gtc.2014.02.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Eosinophilic esophagitis (EoE) is a.complex, polygenia.disorder caused by genetic predisposition and environmental exposures. Because of the recent emergence of EoE as a bona fide global health concern, a paucity of available therapeutic and diagnostic options exists. However, rapid progress has been made in an effort to rectify this lack and to improve understanding of the factors that cause EoE. This article highlights key advances in elucidating the genetic (and epigenetic) components involved in EoE.
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页码：269 / +
页数：14
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