A multi-step peptidolytic cascade for amino acid recovery in chloroplasts

被引：0

作者：

Teixeira, Pedro F. ^{[1
]}

Kmiec, Beata ^{[1
]}

Branca, Rui M. M. ^{[2
,3
]}

Murcha, Monika W. ^{[4
]}

Byzia, Anna ^{[5
]}

Ivanova, Aneta ^{[4
]}

Whelan, James ^{[6
]}

Drag, Marcin ^{[5
]}

Lehtio, Janne ^{[2
,3
]}

Glaser, Elzbieta ^{[1
]}

机构：

[1] Stockholm Univ, Dept Biochem & Biophys, Arrhenius Labs Nat Sci, Stockholm, Sweden

[2] Sci Life Lab, Dept Oncol Pathol, Clin Prote Mass Spectrometry, Stockholm, Sweden

[3] Karolinska Inst, Stockholm, Sweden

[4] Univ Western Australia, ARC Ctr Excellence Plant Energy Biol, Crawley, WA, Australia

[5] Wroclaw Univ Technol, Dept Chem, Div Bioorgan Chem, Wroclaw, Poland

[6] La Trobe Univ, Sch Life Sci, Dept Anim Plant & Soil Sci, ARC Ctr Excellence Plant Energy Biol, Bundoora, Vic, Australia

来源：

NATURE CHEMICAL BIOLOGY | 2017年 / 13卷 / 01期

基金：

瑞典研究理事会;

关键词：

TARGETING PEPTIDE DEGRADATION; LEUCINE AMINOPEPTIDASE; PROTEIN MATURATION; MITOCHONDRIA; PATHWAY; OLIGOPEPTIDASE; LOCALIZATION; PROTEOLYSIS; PREP;

D O I：

10.1038/NCHEMBIO.2227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plastids (including chloroplasts) are subcellular sites for a plethora of proteolytic reactions, required in functions ranging from protein biogenesis to quality control. Here we show that peptides generated from pre-protein maturation within chloroplasts of Arabidopsis thaliana are degraded to amino acids by a multi-step peptidolytic cascade consisting of oligopeptidases and aminopeptidases, effectively allowing the recovery of single amino acids within these organelles.

引用

页码：15 / 17

页数：3

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