A lysosome targetable fluorescent probe for endogenous imaging of hydrogen peroxide in living cells

被引：87
|
作者：
Reja, Shahi Imam [1 ]
Gupta, Muskan [2 ]
Gupta, Neha [1 ]
Bhalla, Vandana [1 ]
Ohri, Puja [3 ]
Kaur, Gurcharan [2 ]
Kumar, Manoj [1 ]
机构：
[1] Guru Nanak Dev Univ, UGC Sponsored Ctr Adv Studies 2, Dept Chem, Amritsar, Punjab, India
[2] Guru Nanak Dev Univ, Dept Biotechnol, Amritsar, Punjab, India
[3] Guru Nanak Dev Univ, Dept Zool, Amritsar, Punjab, India
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 26期
关键词：
NITRIC-OXIDE; H2O2; MITOCHONDRIA;
D O I：
10.1039/c6cc09127j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A lysosome targetable naphthalimide based fluorescent probe (LyNC) has been designed and synthesized which detects hydrogen peroxide (H2O2) with high selectivity and sensitivity in brain tissues and in living nematodes among various ROS/RNS tested. Further, the probe LyNC was successfully employed in exogenous and endogenous imaging of H2O2 in living cell lines.
引用
收藏
页码：3701 / 3704
页数：4
相关论文
共 50 条
  • [1] A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells
    Liu, Tianyu
    Xu, Zhaochao
    Spring, David R.
    Cui, Jingnan
    ORGANIC LETTERS, 2013, 15 (09) : 2310 - 2313
  • [2] A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells
    Dickinson, Bryan C.
    Chang, Christopher J.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (30) : 9638 - +
  • [3] Visualization of Endogenous and Exogenous Hydrogen Peroxide Using A Lysosome-Targetable Fluorescent Probe
    Kim, Dabin
    Kim, Gyoungmi
    Nam, Sang-Jip
    Yin, Jun
    Yoon, Juyoung
    SCIENTIFIC REPORTS, 2015, 5
  • [4] Visualization of Endogenous and Exogenous Hydrogen Peroxide Using A Lysosome-Targetable Fluorescent Probe
    Dabin Kim
    Gyoungmi Kim
    Sang-Jip Nam
    Jun Yin
    Juyoung Yoon
    Scientific Reports, 5
  • [5] A new lysosome-targetable fluorescent probe for detection of endogenous hydrogen polysulfides in living cells and inflamed mouse model
    Liang, Li
    Li, Weiqing
    Zheng, Jinrong
    Li, Ruixi
    Chen, Haiyan
    Yuan, Zhenwei
    BIOMATERIALS SCIENCE, 2020, 8 (01) : 224 - 231
  • [6] A new lysosome-targetable fluorescent probe with a large Stokes shift for detection of endogenous hydrogen polysulfides in living cells
    Ren, Yanshen
    Zhang, Lulu
    Zhou, Ziyan
    Luo, Yanjun
    Wang, Suilou
    Yuan, Shengtao
    Gu, Yueqing
    Xu, Yungen
    Zha, Xiaoming
    ANALYTICA CHIMICA ACTA, 2019, 1056 : 117 - 124
  • [7] A lysosome-targetable fluorescent probe for imaging ONOO- in living cells and animals
    Feng, Weiyong
    Feng, Guoqiang
    DYES AND PIGMENTS, 2019, 164 : 174 - 181
  • [8] A lysosome-targetable and two-photon fluorescent probe for imaging endogenous β-galactosidase in living ovarian cancer cells
    Huang, Jinxin
    Li, Nan
    Wang, Qianqian
    Gu, Yueqing
    Wang, Peng
    SENSORS AND ACTUATORS B-CHEMICAL, 2017, 246 : 833 - 839
  • [9] A nucleus targetable fluorescent probe for ratiometric imaging of endogenous NO in living cells and zebrafishes
    Zhao, Liang
    Huang, Zhenlong
    Ma, Daqing
    Yan, Yu
    Zhang, Xinfu
    Xiao, Yi
    ANALYST, 2021, 146 (13) : 4130 - 4134
  • [10] A Ratiometric Fluorescent Probe for Imaging Hydrogen Peroxide in Living Cells
    Yang, Min
    Xia, Lili
    Zhou, Xiaoqin
    Jia, Chengli
    Ji, Min
    Wang, Peng
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (09) : 2888 - 2894
12345