This work focuses on the steady-state and transient thermal-hydraulic analyses for PWR cores using wire wraps in a hexagonal array with either U (45% w/o)-ZrH(1.6) (referred to as U-ZrH(1.6)) or UO(2) fuels. Equivalences (thermal-hydraulic and neutronic) were created between grid spacer and wire wrap designs, and were used to apply results calculated for grid spacers to wire wrap designs. Design limits were placed on the pressure drop, critical hear flux (CHF), fuel and cladding temperature and vibrations. The vibrations limits were imposed for flow-induced vibrations (FIV) and thermal-hydraulic vibrations (THV). The transient analysis examined an overpower accident, loss of coolant accident (LOCA) and loss of flow accident (LOFA). The thermal-hydraulic performance of U-ZrH(1.6) and UO(2) were found very similar. Relative to grid spacer designs, wire wrap designs were found to have smaller fretting wear, substantially lower pressure drop and higher CHE As a result, wire wrap cores were found to offer substantially higher maximum powers than grid spacer cores, allowing for a 25% power increase relative to the grid spacer uprate [Shuffler, C.A., Malen, J.A., Trant, J.M., Todreas, N.E., 2009a. Thermal-hydraulic analysis for grid supported and inverted fueled PWR cores. Nuclear Technology (this special issue devoted to hydride fuel in LWRs)] and a 58% power increase relative to the reference core. (C) 2009 Elsevier B.V. All rights reserved.