The Effect of Unsaturation on the Formation of Self-Assembled Gels from Fatty Acid L-Serine Amides and their Cytotoxicity Towards Caco-2 Cancer Cells

被引：8

作者：

Lim, Li Yun Grace ^{[1
]}

Su, Yingying ^{[2
]}

Braet, Filip ^{[2
]}

Thordarson, Pall ^{[1
]}

机构：

[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia

[2] Univ Sydney, Australian Key Ctr Microscopy & Microanal, Sydney, NSW 2006, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2009年 / 62卷 / 07期

基金：

澳大利亚研究理事会;

关键词：

DELIVERY; GROWTH;

D O I：

10.1071/CH09211

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of saturated and unsaturated fatty acid L-serines 3 were synthesized and their ability to form self-assembled gels was investigated. The saturated (lauroyl 3a and steraoyl 3b) and monounsaturated (oleoyl 3c) fatty acid L-serines form gels in both water and organic solvent, whereas the diunsaturated linoleyl-L-serine 3d does not form gels in these solvents, indicating that unsaturation adversely affects the gelation process. Cytotoxicity studies on these compounds with Caco-2 cancer cells in vitro show that these gels are only moderately cytotoxic at concentrations up to 0.5 mM, making them a promising candidate for applications such as drug delivery.

引用

页码：653 / 656

页数：4