Probing the mechanism of viral Inhibition by the radical SAM enzyme, Viperin

被引:0
|
作者
Ghosh, Soumi [1 ]
Makins, Caitlyn [1 ]
Roman-Melendez, Gabriel [1 ]
Dumbrepatil, Arti [1 ]
Patel, Ayesha [1 ]
Marsh, E. Neil [1 ]
机构
[1] Univ Michigan, Chem, Ann Arbor, MI 48109 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
96
引用
收藏
页数:1
相关论文
共 50 条
  • [1] The antiviral protein viperin is a radical SAM enzyme
    Duschene, Kaitlin S.
    Broderick, Joan B.
    FEBS LETTERS, 2010, 584 (06) : 1263 - 1267
  • [2] Structural studies of viperin, an antiviral radical SAM enzyme
    Fenwick, Michael K.
    Li, Yue
    Cresswell, Peter
    Modis, Yorgo
    Ealick, Steven E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (26) : 6806 - 6811
  • [3] Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2)
    Ebrahimi, Kourosh Honarmand
    Rowbotham, Jack S.
    McCullagh, James
    James, William S.
    CHEMBIOCHEM, 2020, 21 (11) : 1605 - 1612
  • [4] Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin
    Chakravarti, Arpita
    Selvadurai, Kiruthika
    Shahoei, Rezvan
    Lee, Hugo
    Fatma, Shirin
    Tajkhorshid, Emad
    Huang, Raven H.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (36) : 14122 - 14133
  • [5] A Novel Radical SAM mechanism mediated by the Interferon-Inducible Protein Viperin
    Dumbrepatil, Arti Baban
    Malec, Paige
    Ghosh, Soumi
    Patel, Ayesha
    Kennedy, Robert T.
    Marsh, E. Neil G.
    FASEB JOURNAL, 2018, 32 (01):
  • [6] Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily
    Hoffman, Brian M.
    Broderick, William E.
    Broderick, Joan B.
    ANNUAL REVIEW OF BIOCHEMISTRY, 2023, 92 : 333 - 349
  • [7] Structural characterization reveals that viperin is a radical S-adenosyl-L-methionine (SAM) enzyme
    Shaveta, Goyal
    Shi, Jiahai
    Chow, Vincent T. K.
    Song, Jianxing
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (03) : 1390 - 1395
  • [8] The radical-SAM enzyme Viperin catalyzes reductive addition of a 5′-deoxyadenosyl radical to UDP-glucose in vitro
    Ebrahimi, Kourosh Honarmand
    Carr, Stephen B.
    McCullagh, James
    Wickens, James
    Rees, Nicholas H.
    Cantley, James
    Armstrong, Fraser A.
    FEBS LETTERS, 2017, 591 (16): : 2394 - 2405
  • [9] Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity
    Ghosh, Soumi
    Marsh, E. Neil G.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (33) : 11513 - 11528
  • [10] Viperin: A Radical SAM-dependent Approach in the Regulation of Farnesylpyrophosphate Synthase
    Ghosh, Soumi
    Makins, Caitlyn
    Roman-Melendez, Gabriel D.
    Patel, Ayesha
    Malec, Pare A.
    Kennedy, Robert T.
    Marsh, E. Neil G.
    FASEB JOURNAL, 2018, 32 (01):