Evaluation of Clinically Efficacious Opioid Analgesics for Biased Agonism and Correlations to Respiratory Suppression and Antinociception

被引:0
|
作者
Schmid, Cullen [1 ]
Bohn, Laura [1 ]
机构
[1] Scripps Res Inst, Jupiter, FL USA
关键词
mu-opioid receptors; beta arrestin; Functional Selectivity; g protein signaling;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
M261
引用
收藏
页码:S270 / S271
页数:2
相关论文
共 9 条
  • [1] Biased versus Partial Agonism in the Search for Safer Opioid Analgesics
    Neto, Joaquim Azevedo
    Costanzini, Anna
    De Giorgio, Roberto
    Lambert, David G.
    Ruzza, Chiara
    Calo, Girolamo
    MOLECULES, 2020, 25 (17):
  • [2] Biased Agonism as an Emerging Strategy in the Search for Better Opioid Analgesics
    Piekielna-Ciesielska, Justyna
    Wtorek, Karol
    Janecka, Anna
    CURRENT MEDICINAL CHEMISTRY, 2020, 27 (09) : 1562 - 1575
  • [3] Clinically Employed Opioid Analgesics Produce Antinociception via μ-δ Opioid Receptor Heteromers in Rhesus Monkeys
    Yekkirala, Ajay S.
    Banks, Matthew L.
    Lunzer, Mary M.
    Negus, Stevens S.
    Rice, Kenner C.
    Portoghese, Philip S.
    ACS CHEMICAL NEUROSCIENCE, 2012, 3 (09): : 720 - 727
  • [4] Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics
    Bedini, Andrea
    Cuna, Elisabetta
    Baiula, Monica
    Spampinato, Santi
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (09)
  • [5] A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory Depression
    Eubanks, Lisa M.
    Blake, Steven
    Natori, Yoshihiro
    Ellis, Beverly
    Bremer, Paul T.
    Janda, Kim D.
    ACS CHEMICAL BIOLOGY, 2021, 16 (02) : 277 - 282
  • [6] Innovative Opioid Peptides and Biased Agonism: Novel Avenues for More Effective and Safer Analgesics to Treat Chronic Pain
    Bedini, Andrea
    Spampinato, Santi
    CURRENT MEDICINAL CHEMISTRY, 2018, 25 (32) : 3895 - 3916
  • [7] Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics
    Pedersen, Mie Fabricius
    Wrobel, Tomasz Marcin
    Marcher-Rorsted, Emil
    Pedersen, Daniel Sejer
    Moller, Thor Christian
    Gabriele, Federica
    Pedersen, Henrik
    Matosiuk, Dariusz
    Foster, Simon Richard
    Bouvier, Michel
    Brauner-Osborne, Hans
    NEUROPHARMACOLOGY, 2020, 166
  • [8] Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine
    Imam, Mohammad Zafar
    Kuo, Andy
    Ghassabian, Sussan
    Cai, Yunxin
    Qin, Yajuan
    Li, Tingyou
    Smith, Maree T.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 871
  • [9] Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism
    Liu, Nai-Jiang
    Murugaiyan, Vijaya
    Storman, Emiliya M.
    Schnell, Stephen A.
    Kumar, Arjun
    Wessendorf, Martin W.
    Gintzler, Alan R.
    JOURNAL OF NEUROSCIENCE, 2017, 37 (46): : 11181 - 11191