Three new pseudodistomins, piperidine alkaloids from the ascidian Pseudodistoma megalarva

被引：46
|
作者：
Freyer, AJ
Patil, AD
Killmer, L
Troupe, N
Mentzer, M
Carte, B
Faucette, L
Johnson, RK
机构：
[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT SCI,R&D,KING OF PRUSSIA,PA 19406
[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT PHYS & STRUCT CHEM,R&D,KING OF PRUSSIA,PA 19406
来源：
JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 10期
关键词：
D O I：
10.1021/np9701438
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioassay-guided fractionation of the MeOH-CH2Cl2 extract of the Micronesian ascidian Pseudodistoma megalarva yielded three new piperidine alkaloids, pseudodistomins D-F (3-5) and the previously reported pseudodistomins B and C (1 and 2). The structure and stereochemistry of these compounds were established by interpretation of spectral data. Pseudodistomins B-F were found to be active in a cell-based assay for DNA damage induction, but the activity was due to an alternative mechanism.
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页码：986 / 990
页数：5
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