A metabolic profiling approach to an Italian-sage leaf extract (SoA541) defines its antioxidant and anti-acetylcholinesterase properties

被引：27

作者：

Pacifico, Severina ^{[1
]}

Piccolella, Simona ^{[1
]}

Lettieri, Annamaria ^{[1
]}

Nocera, Paola ^{[1
]}

Bollino, Flavia ^{[2
]}

Catauro, Michelina ^{[2
]}

机构：

[1] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, Via Vivaldi 43, I-81100 Caserta, Italy

[2] Univ Naples 2, Dept Ind & Informat Engn, Via Roma 29, I-81031 Aversa, Italy

来源：

JOURNAL OF FUNCTIONAL FOODS | 2017年 / 29卷

关键词：

Salvia officinalis; LC-ESI-MS/MS; Phenols; Abietane diterpenes; Cytotoxicity; Antioxidant activity; SALVIA-OFFICINALIS-L; RADICAL SCAVENGING ACTIVITY; ALZHEIMERS-DISEASE; ROSMARINUS-OFFICINALIS; CARNOSIC ACID; MEDICINAL-PLANTS; ESSENTIAL OILS; CAFFEIC ACID; ACETYLCHOLINESTERASE INHIBITORS; MASS-SPECTROMETRY;

D O I：

10.1016/j.jff.2016.11.031

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

LC-MS/MS techniques were applied to analyze, quali- and quantitatively, a phenol extract from leaves of Salvia officinalis, cultivated in the Campania Region (Italy). It accounted for similar to 50% of abietane diterpenes, similar to 40% of phenylpropanoid constituents, and 10% flavonoids, and so called SoA541. Lignin oligomers were detected for the first time as sage constituents. SoA541 exerted anti-lipoperoxidative and antioxidant properties at dose levels <125 mu g/mL on SH-SY5Y cells, and its ability to inhibit the AChE enzyme was far greater than donepezil. The anti-AChE effectiveness was dose-dependent up to a maximum (62.5 mu g/mL), beyond which the effect decreased. The data obtained encourage further research aimed at evaluating a potential use of the "Campania" sage in the prevention of CNS diseases in animal models. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1 / 9

页数：9