Organic syntheses based on 2-oxoglutaric acid .5. Syntheses of novel 2H-1,4-benzothiazines and a 2,5-dihydro-1,5-benzothiazepine

被引：7
|
作者：
Blitzke, T
Sicker, D
Wilde, H
机构：
[1] Institut für Organische Chemie, Universität Leipzig, D-04103 Leipzig
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 02期
关键词：
D O I：
10.1002/jhet.5570340215
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Syntheses aimed on the incorporation in heterocycles of segments originating in the precursor 2-oxoglutaric acid are described. Cylocondensation of dimethyl 2-oxoglutarate 1, dimethyl 3-bromo-2-oxoglutarate 2, and dimethyl (E)-2-oxoglutaconate 3 with 2-aminobenzenethiol gave rise to the novel 2H-1,4-benzothiazines 4 and 5, and the 2,5-dihydro-1,5-benzothiazepine 6, respectively, by incorporation of either the segments C-1/C-2 or C-2/C-3 or C-3/C-4/C-5 of the precursor.
引用
收藏
页码：453 / 455
页数：3
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